WebMar 29, 2024 · Whilst principally known for its role in proinflammatory gene induction, IRF8 also reportedly takes part in a second phase of interferon induction in dendritic cells in response to Newcastle Disease virus (NDV) which triggers IFN induction via activation of RIG-I dependent pathways ( 49 ). WebJan 22, 2024 · Although IRF8 normally suppresses B cell differentiation to plasma cells , a process that positively contributes to EBV reactivation , the results of our current work and the studies of others support a model in which IRF8 facilitates the reactivation of EBV upon lytic induction . IRF8 plays a key role in maintaining caspase-1 expression, a ...
Interferon regulatory factor 8 regulates caspase-1 expression to ...
WebApr 4, 2024 · Moreover, IRF8 was detected as a novel fusion partner of IGH in DLBCL, 39,40 and this fusion resulted in higher IRF8 expression levels. 39 In a mouse model of the IGH-IRF8 fusion, this deregulation resulted in lower survival of these mice compared with the WT control; however, no increased incidence of B-cell lymphoma was observed. 41 IRF8 is ... WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this … dodge and burn tool in affinity photo
IRF8 - an overview ScienceDirect Topics
WebApr 1, 2024 · In the TCGA dataset, IRF8 upregulation was most significantly associated with AML and diffuse large B-cell lymphoma, further supporting its utility as a marker of hematopoietic neoplasms [7]. In fact, the only sample positive for IRF8 on the carcinoma TMA turned out to be a testicular diffuse large B-cell lymphoma mistakenly added. … WebIRF8/PU.1-deficient naive B cells expressed normal amounts of a suite of transcription factors implicated in late B cell differentiation, including Irf4, Bach2, Spib, and Ets2 but, … WebMar 2, 2016 · PU.1, IRF4 and IRF8 regulate early B-cell differentiation To investigate the pro/pre-B-cell compartment in more detail, BM derived CD19 + B220 + B cells of all mutant mice were... dodge and burn tools