Cyp46a1 protein
WebJan 1, 2024 · The present study demonstrates the diverse potential effects of CYP46A1 deficiency on brain functions and identifies important proteins that could be affected by this deficiency Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model. WebThis endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. ... CYP46A1 open_in_new. Ensembl ID . ENST00000261835 ...
Cyp46a1 protein
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WebCat.No. : CYP46A1-03H Optional Service: Optional requirements on this protein Product Overview : Recombinant human CYP46A1 and human CYP-reductase without tag was coexpressed in Escherichia coli. WebCYP46A1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. Assigned HPA protein class (es) for the encoded ...
WebMar 21, 2024 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Alzheimer Disease, Familial, 1 and Cerebrotendinous Xanthomatosis . Among its related pathways are Oxidation by … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein … ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases … SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases … NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with … FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein … CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein … ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. … PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases … WebCYP46A1 belongs to cytochrome P450 family of enzymes and it localize to ER/microsomes as single-pass membrane protein, and unlike other cytochrome P450 sterol hydroxylases that are predominantly expressed …
WebRecombinant Human CYP46A1 Protein [H00010858-Q01] - 12.5% SDS-PAGE Stained with Coomassie Blue. Product Details. Summary. Reactivity: Hu Species Glossary: Applications: WB, ELISA, PA, AP: Order Details 100% Guarantee on every product. Recombinant Human CYP46A1 GST (N-Term) Protein Summary ... WebJan 1, 2024 · Consistent with HMGCR, CYP46A1 protein level was up-regulated in response to Aβ treatment. Based on our findings, we can suggest that increased expression of CYP46A1 level can be a regulatory positive feedback to keep neurons active in order to inhibit cholesterol accumulation in case of increased levels of HMGCR protein and …
WebAnti-CYP46A1抗体. Product Properties. Cat Code Product Name Clonality Cross reactivity Application MW(kDa). 508573 Anti-CYP46A1 Rabbit pAb Rabbit pAb Human,Mouse,Rat WB 57kDa. Sensitivity . Anti-CYP46A1抗体Immunogen Recombinant protein of human CYP46A1. Host Rabbit. Clone Number . Anti-CYP46A1抗体Antibody type Polyclonal …
WebOct 29, 2024 · CYP46A1 mRNA is predominantly expressed within the brain (A) but not in the periphery (B). Brain expression is highest in the striatum > cortex > hippocampus > cerebellum. Box plots are shown as median … dr heidi mandry high point ncWebAug 4, 2024 · Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in … dr heidi mcnaney stuart flWebAug 25, 2024 · Protein Data Bank in Europe. Bringing Structure to Biology. Examples: hemoglobin, BRCA1_HUMAN. ... Gene names: CYP46, CYP46A1 Sequence domains: Cytochrome P450. Ligands and Environments Cofactor: 1 x HEM. 1 bound ligand: 1 x YCJ. No modified residues. Experiments and Validation Details. dr heidi murley ft thomas ky• Human CYP46A1 genome location and CYP46A1 gene details page in the UCSC Genome Browser. • UniProt entry on Cholesterol-24 hydroxylase • HMDB Database entry • RCSB Protein Data Bank Entry ent of san antonio locationsWebApr 1, 2024 · Reduced Cyp46A1 level at terminal stages of prion disease in prion-infected mice and sCJD patients. To assess a potential role of Cyp46A1 in prion disease, we analyzed its protein levels at the terminal stage of prion disease after intracerebral (i.c.) inoculation of three well established scrapie strains (RML, 22L and ME7) into FVB mice. ent of southern nevadaWebMar 2, 2024 · This aberrant oligomerization of ATAD3A induced AD-like hyperconnectivity of MAMs and impaired neuronal cholesterol turnover by inhibiting CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1)... ent of southeast iowaWebCYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease CYP46A1 inhibition, brain cholesterol accumulation and … ent of putnam