Bivalirudin cardiopulmonary bypass

Author: hwyn

August undefined, 2024

WebReverso Context oferă traducere în context din engleză în română pentru "coronary artery bypass graft surgery", cu exemple: Following coronary artery bypass graft surgery, patients administered Dynastat have a higher risk of adverse events, such as cardiovascular/ thromboembolic events, deep surgical infections and sternal wound healing complications. WebApr 30, 2011 · Extracorporeal membrane oxygenation (ECMO) after cardiac operations (postcardiotomy) is commonly used for the treatment of acute heart failure refractory to drug treatment. Bleeding and thromboembolic events are the most common complications of postcardiotomy ECMO. The present study is a retrospective comparison of the …

Dose Estimation for Bivalirudin during Pediatric Cardiopulmonary Bypass ...

WebMay 9, 2012 · Bivalirudin has been proposed as the sole anticoagulant in patients under extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass. Owing to the pharmacodynamic properties of ... WebDec 10, 2024 · In the pooled data, bivalirudin was associated with a reduction in serious bleeding rates compared with heparin and, in the STEMI subgroup, a 30-day mortality … radio nihonara

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WebThe hypothesis that dabigatran would provide sufficient anticoagulation for cardiopulmonary bypass was tested in a first-use, proof-of-concept study using a rabbit model of cardiopulmonary bypass that included a comparison group receiving heparin. The dabigatran loading dose and maintenance infusions were designed after first … WebApr 6, 2024 · It is in the direct thrombin inhibitor class of drugs. This activity reviews the indications, action, and contraindications for bivalirudin as a valuable agent in the … WebAlthough the reported clinical experience with bivalirudin in cardiac surgery is reviewed, operative techniques for the perfusionist/surgeon team are discussed in detail. We recognize that the use of bivalirudin during cardiopulmonary bypass is evolving and modifications of technique will undoubtedly occur as further data and experience accumulate. radionics uk

Bivalirudin Dosing Requirements in Adult Patients on ... - LWW

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WebBackground. Despite high-dose heparin anticoagulation, cardiopulmonary bypass (CPB) is still associated with marked hemostatic activation. The purpose of this study was to determine whether a reduced dose of bivalirudin, added as an adjunct to heparin, would reduce thrombin generation and circulating markers of inflammatory system activation … WebBivalirudin is metabolized by intracellular proteolysis, with 20% excreted unchanged by the kidneys. Wolstencroft, Arnold and Anderson present a study using allometry to determine appropriate bivalirudin infusion rates for pediatric patients requiring bivalirudin for cardiopulmonary bypass (CPB) anticoagulation 1. dragonjaWebHIT complicates the management of patients presenting for cardiac surgery, particularly those who need cardiopulmonary bypass (CPB) which requires a large dose of UFH. A portion of these patients will have significant thrombotic complications referred to as HITT (Heparin-induced thrombocytopenia with thrombosis). radionice za djecu rijeka

"WebMay 9, 2012 · Owing to its pharmacological profile, bivalirudin is rapidly cleaved by proteolytic enzymes, and its half-life is about 25 minutes when the renal function is normal [].The use of bivalirudin for cardiopulmonary bypass (CPB) [] and ECMO [] is a feasible option.However, it is recommended that, during CPB, blood stagnation in the circuit be … " - Bivalirudin cardiopulmonary bypass

Bivalirudin cardiopulmonary bypass

Bivalirudin during cardiopulmonary bypass in patients …

WebView bivalirudin information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, ... in patients proceeding to percutaneous coronary intervention or coronary artery bypass surgery without cardiopulmonary bypass for bivalirudin Initially by intravenous injection. Adult Initially 100 micrograms/kg for 1 dose, then ... WebThe hypothesis that dabigatran would provide sufficient anticoagulation for cardiopulmonary bypass was tested in a first-use, proof-of-concept study using a rabbit …

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WebTY - JOUR T1 - Use of bivalirudin as an anticoagulant during cardiopulmonary bypass. AU - Veale,James J, AU - McCarthy,Harry M, AU - Palmer,George, AU - Dyke,Cornelius M, PY - 2005/12/15/pubmed PY - 2006/2/8/medline PY - 2005/12/15/entrez SP - 296 EP - 302 JF - The journal of extra-corporeal technology JO - J Extra Corpor Technol VL - 37 IS - 3 … WebInfants with heparin-induced thrombocytopenia (HIT) represent a challenging and high-risk group of patients when they require cardiopulmonary bypass (CPB). Bivalirudin offers many potential pharmacologic advantages over other nonheparin anticoagulants for such patients. We describe our protocol for …

WebHeparin is used to provide anticoagulation during cardiopulmonary bypass, but it has disadvantages including potential development of antiplatelet factor 4/heparin antibodies. A recommended alternative to heparin, bivalirudin, has its own disadvantages including the lack of a reversal agent. Dabigatran may be a better alternative in patients ... WebBackground: The coronary artery bypass grafting (CABG) heparin-induced thrombocytopenia thrombosis syndrome (HITTS) on- and off-pump safety and efficacy …

WebFeb 3, 2024 · A typical adult based bivalirudin regimen during cardiopulmonary bypass uses a loading dose of 1 mg.kg ‐1 and a circuit prime (volume L x 13 mg) with a subsequent intravenous infusion 2.5 mg.h ‐1 .kg ‐1. Dose in children remains unknown. We wished to determine a practical bivalirudin dosing schedule for children undergoing surgery with ... WebFeb 1, 2004 · We investigated the use of bivalirudin as an anticoagulant therapy during cardiopulmonary bypass in 20 patients who underwent coronary artery bypass …

WebReverso Context oferă traducere în context din engleză în română pentru "artery bypass graft surgery", cu exemple: Following coronary artery bypass graft surgery, patients administered Dynastat have a higher risk of adverse events, such as cardiovascular/ thromboembolic events, deep surgical infections and sternal wound healing complications.

WebApr 1, 2010 · ObjectiveTo evaluate the use of recombinant factor VIIa (rFVIIa) to reverse major bleeding from newer parenteral anticoagulant therapy.Data sourcesMEDLINE/PubMed was searched from January 2000 through December 2009 using the terms recombinant factor VIIa, rFVIIa, NovoSeven, enoxaparin, argatroban, … radio nihuil 98.9 fmWebNov 3, 2010 · Antiphospholipid syndrome (APLS) is a rare syndrome mainly characterized by several hyper-coagulable complications and therefore, implicated in the operated cardiac surgery patient. APLS comprises clinical features such as arterial or venous thromboses, valve disease, coronary artery disease, intracardiac thrombus … dragon j20WebDec 15, 2024 · Bivalirudin reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... During “off-pump” cardiac surgery (i.e., without cardiopulmonary bypass), 0.75 mg/kg by direct IV injection, followed by 1.75 mg/kg per hour by continuous IV infusion to maintain an ACT >300 seconds has been used. radio nihonWebFeb 1, 2024 · However, pharmacokinetic studies during cardiac surgery are only available for bivalirudin. 11,12 During surgery with … dragonjackWebJun 19, 2024 · On-pump:Initial bolus: 1 mg/kg, followed by continuous infusion 2.5 mg/kg/hour; 50 mg bolus added to priming solution of cardiopulmonary bypass (CPB) circuit. Additional boluses of 0.1 to 0.5 mg/kg may … dragon jack o pose dragonja grenzübergangWebAnesthesia & Analgesia: June 2004 - Volume 98 - Issue 6 - p 1635-1639. doi: 10.1213/01.ANE.0000114072.71353.D5. Free. We treated persistent hemorrhage after cardiopulmonary bypass in a heart transplant recipient who had received anticoagulation with the direct thrombin inhibitor bivalirudin by a combination therapy aimed at reducing … radio nihuil 680